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Tryptophan more readily enters the brain, but 5-HTP requires one less step to convert into serotonin.

But SSRIs can have serious side effects and don’t work for everyone, possibly up to 40 percent of those who try them (1).

Note that it is not considered safe to mix any of these amino acid supplements with antidepressant medications (4).

Do so only if you are working with a knowledgeable health care professional. Tryptophan: Tryptophan might seem like a logical serotonin supplement to try first since tryptophan is a precursor of serotonin.

For decades, manufacturers shied away from selling this supplement, but it’s now readily available and widely known to be safe.

5-HTP (5-hydroxytryptophan): 5-HTP could be considered as either an amino acid or herbal supplement.

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now there are risks to stepping out on your spouses.